Epazote is such an herb. Epazote is used medicinally to treat internal parasites. Epazote is an abundant weed in Mexico and parts of northern South America. There, its bitter, musky, lemon flavor is used to spice up everything from beans and squash to pork and crab cakes. Young leaves can be wilted and added to soups or stews or combined with other greens, just as chicory or sorrel would be used in early spring. It is often used with other herbs, like Mexican Oregano and Cilantro, and, of course, chilies.
A tender perennial herb, Epazote has proven itself hardy in our Zone 8 winters. It dies back to the ground each winter but returns in spring. A heat loving herb whose flavors are best when grown in full sun, Epazote can be grown in a medium size container and placed on sunny window or under lights for the winter, if your winters dip much below 20.